Bayer Leverkusen
Kyriakos Papadopoulos returns from suspension for the hosts and is likely to come into the starting XI at the heart of the defence alongside Jonathan Tah.
Karim Bellarabi is set to partner Javier Hernandez in attack in a 4-4-2 formation.
Charles Aranguiz, Tin Jedvaj and Seung-Woo Ryu are all sidelined, while Lars Bender is still suffering with an ankle problem.
Barcelona
Dani Alves misses out through suspension, with Adriano expected to come into the starting XI at right-back.
Luis Enrique is without injured quartet Rafinha, Douglas, Jeremy Mathieu and Sergi Roberto, while Gerard Pique and Andres Iniesta will be rested for the European champions.
Javier Mascherano could start in midfield, while while Munir is set to replace the injury Neymar in attack.
Match Facts
Barcelona have won 14 of their last 16 matches in the Champions League (including qualifiers). Barcelona win 2.45
Barcelona have won their last 6 matches against Leverkusen in all competitions. Barcelona win 2.45
Barcelona have scored at least 2 goals in 9 of their last 10 matches in the Champions League (including qualifiers). Over 2.5 goals 1.48
Barcelona have scored at least 2 goals in their last 6 matches against Leverkusen in all competitions. Over 2.5 goals 1.48
Leverkusen have seen over 2.5 goals in 6 of their last 7 matches against Barcelona in all competitions. Over 2.5 goals 1.48
* Odds from
Prediction
Bayer Leverkusen's progression to the next round of the Champions League is in their hands, but they need a positive result and to hope results go their way elsewhere. The Bundesliga side, though, have lost their last six meetings with Barcelona, conceding 18 goals in the process.
Barcelona will name a weakened XI for their trip to Germany having already guaranteed top spot in Group E. The Blaugrana have won 14 of their last 16 Champions League encounters and will want to end the group stages on a high having taken 13 of a possible 15 points thus far.
The hosts will push for the the result they need to progress, but could come undone on Wednesday night.
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