The trip to Catalunya will be the first in a sequence of six games in the space of 20 days, which includes an important Champions League clash with Benfica.
Atletico are enjoying a run of 10 games without defeat, seven of which have been draws, but suffered a blow in the 1-0 Liga victory over Espanyol on Saturday, with midfielder Tiago suffering a broken leg.
However, Simeone is confident the depth of his squad means they will be able to cope in the absence of the Portuguese veteran as they enter a hectic period.
"We re-armed the team [against Espanyol] with Saul, Oliver and Koke – three lads from our youth academy," Simeone said.
"The competition gives everyone a chance to play and that's good for everyone and for the team.
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